ICG maleimide馬來酰亞胺,ICG-MAL,吲哚菁綠

英文名：ICG maleimide，ICG-MAL
中文名：吲哚菁綠-馬來酰亞胺
外觀：綠色粉末
溶解度：二氯甲烷
純度：95%+
結構式：

ICG maleimide馬來酰亞胺,ICG-MAL,吲哚菁綠

ICG is a tricarbocyanine-type dye with NIR-absorbing properties (peak absorption around 800 nm) and emission maximum at 807 nm (10% v/vDMSO/PBS). Little absorption in the visible range accounts for the low autofluorescence, tissue absorbance, and scattering at NIR wavelengths (700-900 nm).

The maleimide of the ICG dye offers the opportunity to develop optimal conjugates. Maleimide active group provides an efficient and convenient way to selectively link ICG dye to sulfhydryl groups (free thiol, R-SH) on various substrates (antibodies[1], peptides, proteins, oligonucleotides, small molecule drugs etc.) at neutral (physiological) pH without any activation. Maleimides have very low reactivity with amines, alcohols, and phenols (incl. tyrosine and histidine) and do not react with histidine and methionine thus providing very high labeling selectivity.

It has been reported that conjugation to some antibodies may cause decrease in fluorescence intensity of ICG bound to antibody due to the formation of H-dimers4. However, fluorescence is restored after cell binding and internalization, which can be used to design an activatable NIR fluorescent probe. Fluorescence intensity of the unbound ICG-antibody conjugate can be dramatically increased (up to 50-fold) by addition of SDS and β-mercaptoethanol, which diminishes π- π stacking5.

相關產(chǎn)品：

TCO-PEG-ICG   吲哚菁綠-聚乙二醇-反式環(huán)辛炔

ICG-PEG4-Thiol

ICG-PEG4-NHS

ICG-PEG5-NH2

ICG-PEG4-MAL

ICG-PL-PEG  磷脂化的聚乙二醇

ICG-PL-PEG-FA ICG-PEG-Folate 吲哚菁綠-聚乙二醇-葉酸

ICG-FA-PPD  吲哚菁綠-葉酸修飾PEI-PEG-釓酸

RGD-PLS-ICG  吲哚菁綠-RGD修飾聚乙二醇化脂質體

C18-PEG-ICG

ICG-PEG-Silane 吲哚菁綠-聚乙二醇-硅烷

ICG-PEG-Lipoic acid,  ICG-PEG-LA吲哚菁綠-聚乙二醇-硫辛酸

ICG-PEG-Epoxides (EPOX) 吲哚菁綠-聚乙二醇-環(huán)氧化物

ICG-PEG-Valeric Acids (VA) 吲哚菁綠-聚乙二醇-纈草酸

ICG-PEG-Chloride 吲哚菁綠修飾聚乙二醇氯化物

ICG-PEG-TZ/Tetrazine  吲哚菁綠修飾聚乙二醇四嗪

ICG-PEG-CHEMS 吲哚菁綠修飾聚乙二醇半琥珀酸膽固醇

ICG-PEG-DBCO  吲哚菁綠修飾聚乙二醇環(huán)辛炔

CG-PEG-ICG  吲哚菁綠-聚乙二醇-殼聚糖

ICG-PEG-Chitosan   吲哚菁綠-聚乙二醇-殼聚糖

ICG-PEG-Dextran   吲哚菁綠修飾聚乙二醇葡聚糖/右旋糖酐

ICG-PEG-Galactose  吲哚菁綠修飾聚乙二醇半乳糖

ICG-PEG-Mannose   甘露糖

ICG-PL-PEG-mAb 整合素α(v)β?單克隆抗體

APT-PEG-ICG-Der-02   MUC1適體的靶配體APT-聚乙二醇-吲哚菁綠

ICG-PEG-MTX  甲氨蝶呤

ICG-PEG-DOX  阿霉素

GNR-PEG-ICG  納米金棒-聚乙二醇-吲哚菁綠

GNR-PEG-ICG-FA納米金棒-聚乙二醇-吲哚菁綠-葉酸

Cu9S5@mSiO2-ICG-PEG-LA 核殼結構介孔二氧化硅納米粒子-吲哚菁綠-聚乙二醇-硫辛酸

PEG-PCL-C3-ICG-NPs    PEG-PCL加有機化合物C3-ICG的納米粒

雙功能ICG衍生物ICG-PEG8-Sulfo-OSu

雙功能ICG衍生物ICG-PEG4-Sulfo-OSu

ICG衍生物ICG-Sulfo-OSu

ICG-PL-PEG 磷脂化的聚乙二醇

ICG-PL-PEG-FA葉酸 磷脂化的聚乙二醇

ICG-FA-PPD 吲哚菁綠-葉酸修飾PEI-PEG-釓酸

RGD-PLS-ICG 吲哚菁綠-RGD修飾聚乙二醇化脂質體

ICG-PEG-Lipoic acid, ICG-PEG-LA吲哚菁綠-聚乙二醇-硫辛酸

ICG-PEG-TZ/Tetrazine 吲哚菁綠修飾聚乙二醇四嗪

ICG-PEG-DBCO 吲哚菁綠修飾聚乙二醇環(huán)辛炔

CG-PEG-ICG 吲哚菁綠-聚乙二醇-殼聚糖