文獻：具有聚集誘導發光的氧化還原敏感聚合物膠束用于生物成像和*癌藥物的遞送

鏈接：https://link.springer.com/article/10.1186/s12951-020-00761-9

作者：孫長振,吉祿,王俊,郝平,李春紅,陸奇,林楊何斌鐘志榮&那好

節選：

mPEG-SAA的合成

將mPEG（0.2 g，0.1 mmol）和SAA（0.05 g，0.5 mmol）溶于60 mL無水二氯甲烷中，劇烈攪拌。冰浴下，將吡啶（0.4 mL）逐滴加入混合物中。室溫下攪拌48 h。在攪拌下，向反應體系中加入適量乙酸，以中和體系中生成的鹽。過濾除去沉淀，蒸發濾液，將粗品產物沉淀于大量冷乙醚中。重復此純化步驟數次，得到mPEG-SAA。

Synthesis of mPEG-SAA

The mPEG (0.2 g, 0.1 mmol) and SAA (0.05 g, 0.5 mmol) were dissolved in 60 mL of anhydrous CH2Cl2 with strong stirring. Pyridine (0.4 mL) was added dropwise to the mixture on an ice bath. The mixture was stirred at room temperature for 48 h. An appropriate amount of acetic acid was added to the reaction system under stirring in order to neutralize salts produced in the system. The precipitate was removed by filtration, the filtrate was evaporated and the crude product was precipitated in a large volume of cold diethyl ether. This purification procedure was repeated several times to yield mPEG-SAA.

西安齊岳生物提供相關產品：

DSPE-PEG-GE11(二硬脂酰基磷脂酰乙醇胺-聚乙二醇-*細胞表皮生長因子EGFR靶向肽)

DSPE-PEG-N3

DSPE-PEG-RGD 二硬脂酰基磷脂酰乙醇胺-聚乙二醇-多肽

DSPE-PEG-OX26 mAb（二硬脂酰基磷脂酰乙醇胺-聚乙二醇-*靶向蛋白)

Angiopep-2-PEG-DSPE

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