文獻：Prostate cancer targeted magnetic resonance imaging nanoprobes based on polyethylene glycol polyethyleneimine and superparamagnetic iron oxide

作者：周建華，黃綠，王偉偉，龐俊，鄒艷，帥心濤，高新

文獻鏈接：https://xueshu.baidu.com/usercenter/paper/show?paperid=c51dc88dae42acd9da7f55aeefd5bfbf&site=xueshu_se

摘要：

A water-soluble copolymer of polyethylene glycol grafted polyethyleneimine (mPEG-g-PEI) was obtained by grafting branched polyethyleneimine (hy PEI) onto monomethyl ether polyethylene glycol (mPEG-OH). Superparamagnetic iron oxide nanoparticles (SPIO) were encapsulated by ligand exchange, and then functionalized polyethylene glycol (mal PEG COOH) was combined with activated prostate stem cell antigen (PSCA) monoclonal single chain antibody to obtain a targeted magnetic resonance imaging nanoprobe for prostate cancer cells Research has shown that the particle size of polyethylene glycol grafted polyethyleneimine (mPEI-g-PEG-SPIO) loaded with superparamagnetic iron oxide nanoparticles is about 50nm, which can significantly improve the specific delivery efficiency to prostate cancer cells, thereby significantly reducing the T2 signal intensity of magnetic resonance imaging (MRI) of prostate cancer cells and enhancing the recognition efficiency of prostate cancer. It may become a new nano probe for early diagnosis of prostate cancer MRI or a visible nucleic acid delivery carrier in gene therapy

采用單甲基醚聚乙二醇(mPEG-OH)接枝支化聚乙烯亞胺(hy-PEI),得到水溶性共 聚物聚乙二醇接枝聚乙烯亞胺(mPEG-g-PEI),通過配體交換的方法包裹超順磁性四氧化三鐵納米粒子(SPIO),再通過功能化的聚乙二醇 (mal-PEG-COOH)與活化的前列腺干細胞抗原(PSCA)單克隆單鏈抗體結合,獲得前列腺*細胞靶向核磁共振顯像納米探針.研究表明,負載超順 磁性四氧化三鐵納米粒子的聚乙二醇接枝聚乙烯亞胺(mPEI-g-PEG-SPIO)的粒徑約為50nm,能顯著提高對前列腺*細胞的特異性輸送效率,從 而顯著地降低前列腺*細胞的核磁共振成像(MRI)T2信號強度,增強對前列腺*的識別效率,有可能成為一種前列腺*MRI早期診斷新型納米探針或者基因 治療中一種MRI可見的核酸輸送載體.

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PEI-PEG-SH

PEI-PEG-cRGD

PEI-PLGA

PEI-PLA

PEI-PCL

PEI Hyaluronate (PEI-HA)

PEI-Dextran

PEI-Chitosan

mPEG-PCL-PEI

X-PEI-Y 

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