文獻：基于Diels-Alder反應的可注射緩釋水凝膠的制備及其理化性質

作者：李聰聰，陳道遠，李明慧，張文，張蓬，孫考祥

文獻鏈接：https://xueshu.baidu.com/usercenter/paper/show?paperid=1m690r508t010vb0x72402x0xn322969&site=xueshu_se

摘要：

The aim of this study was to prepare an injectable sustained release hydrogel through drug polymer coupling model and Diels Alder click reaction

Puerarin hyaluronic acid coupling compound (PUE-HA) was prepared by connecting puerarin and hyaluronic acid through amide bond. PUE-HA and 4-arm maleimide polyethylene glycol (4-arm PEG-MAL) were crosslinked through Diels Alder click reaction to prepare injectable sustained-release hydrogel (PUE-HA-PEG) Compared with 1Furan/1MI and 1Furan/2MI hydrogels, the gelation time of 1Furan/4MI hydrogels can be shortened to 1 min. With the increase of MI ratio, the hydrogels have lower degradation rate (21 day degradation rate is less than 60%), better mechanical properties, and more obvious drug release effect

The experimental results show that the ratio of Furan/MI has a significant impact on the physical and chemical properties of injectable sustained-release hydrogels

本研究旨在通過藥物-聚合物偶聯物模型和Diels-Alder點擊反應制備一種可注射緩釋水凝膠.

將葛根素與透明質酸通過酰胺鍵連接得到葛根素-透明質酸偶聯物(PUE-HA),將PUE-HA和四臂馬來酰亞胺聚乙二醇(4-arm-PEG-MAL)通過Diels-Alder點擊反應交聯制備了可注射緩釋水凝膠(PUE-HA-PEG),并考察了三種不同呋喃(Furan)與馬來酰亞胺基(MI)比例對所得水凝膠的膠凝時間,形貌,溶脹度,降解度,葛根素體外釋放,水凝膠力學性能以及水凝膠生物相容性等理化性質的影響.與1Furan/1MI和1Furan/2MI水凝膠相比,1Furan/4MI的水凝膠膠凝時間可縮短至1 min.隨著MI比例的增加,水凝膠具有更低的降解速率(21 d降解率低于60%),更好的力學性能,緩釋釋藥作用更加明顯.

實驗結果表明,Furan/MI的比例對可注射緩釋水凝膠的理化性質具有重大影響.

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