文獻：MPEG-DSPE聚合物膠束用于淋巴結轉移的經淋巴化療

鏈接：https://www.sciencedirect.com/science/article/abs/pii/S0378517315002902

作者：雪莉，董 青，嚴志強，維岳 路，馮玲玲，曹 協 阿，謝作旭，蘇冰霞，劉 敏阿

節選：

本研究制備了甲基聚乙二醇-二硬脂酰磷脂酰乙醇胺/阿霉素（MPEG-DSPE/DOX）膠束用于*淋巴結轉移。制備的MPEG-DSPE/DOX膠束呈球形，粒徑為20  ± 5nm。A375細胞對DOX和MPEG-DSPE/DOX膠束的攝取率分別為51.2%和88.7%。RAW264.7細胞對MPEG-DSPE/羅丹明B膠束的吞噬率比單獨使用羅丹明B低17.2倍。皮下注射后，MPEG-DSPE膠束經淋巴管吸收，在腘窩淋巴結中聚集。 MPEG-DSPE/DOX膠束較單獨DOX能明顯減輕注射部位皮下組織的損傷。建立A375細胞淋巴結轉移裸鼠模型，皮下注射后，MPEG-DSPE/DOX膠束組腘窩淋巴結和髂窩淋巴結重量均明顯低于生理鹽水組和DOX組。MPEG-DSPE/DOX膠束能有效殺傷腘窩淋巴結和髂窩淋巴結中的*細胞。綜上所述，MPEG-DSPE膠束是一種很有前景的*淋巴結轉移的藥物遞送系統。 

Abstract

Lymph node metastasis is one of the major pathways for tumor formation and it is difficult to deliver chemotherapeutics at therapeutic concentrations to lymph node metastasis. This study prepared methyl poly(ethylene glycol)-distearoylphosphatidylethanolamine/doxorubicin (MPEG-DSPE/DOX) micelle for the treatment of lymph node metastasis. The MPEG-DSPE/DOX micelle prepared were of spherical morphology with a particle size of 20 ± 5 nm. The uptake rates of DOX and MPEG-DSPE/DOX micelle by A375 cells were 51.2% and 88.7%, respectively. The phagocytosis rate of MPEG-DSPE/Rhodamine B micelle by RAW264.7 cells was 17.2-fold lower than for Rhodamine B alone. After subcutaneous injection, MPEG-DSPE micelle underwent lymphatic absorption and accumulated in popliteal lymph nodes. MPEG-DSPE/DOX micelle significantly alleviated damage to the subcutaneous tissue of the injection sites compared with DOX alone. We established a model of nude mice bearing lymph node metastasis of A375 cells. After subcutaneous injection, the weights of both the popliteal and iliac lymph nodes of the MPEG-DSPE/DOX micelle group were significantly lower than in the saline and DOX groups. MPEG-DSPE/DOX micelle effectively killed the tumor cells in popliteal and iliac lymph nodes. In conclusion, MPEG-DSPE micelle is a promising drug delivery system for the treatment of lymph node metastasis.

西安齊岳生物提供相關產品：

DSPE-PEG-Paclitaxel

NGR-PEG-DSPE

DSPE-PEG-YEQDPWGVKWWY（二硬脂?；字Ｒ掖及?聚乙二醇-*靶向蛋白)

DSPE-PEG-PQNSKIPGPTFLDPH（二硬脂酰基磷脂酰乙醇胺-聚乙二醇-*靶向蛋白)

Stearic acid-PEG-NHS

DSPE-PEG-RGD(二硬脂?；字Ｒ掖及?聚乙二醇-整合素靶向肽)

ICG-PEG-DPPE

DSPE-PEG-NPC

DPPE-PEG-BIOTIN

DSPE-Cap-Biotin

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