靶向型DSPE-PEG-cRGD納米顆粒增強的眼底光聲與OCT多模態成像

鏈接：https://openurl.ebsco.com/EPDB%3Agcd%3A14%3A1971790/detailv2?sid=ebsco%3Aplink%3Acrawler&id=ebsco%3Adoi%3A10.1515%2Fnanoph-2023-0872&link_origin=none

作者：Du, Fengxian; Niu, Chen; Zeng, Silue; Chen, Jingqin; Liu, Chengbo; Dai, Cuixia

摘要：In this paper, we design a multimodal visible/near-infrared photoacoustic microscopy and optical coherence tomography (VIS/NIR-PAM-OCT) system for imaging both retina and retinal pigment epithelium (RPE)/choroid complex layer. F127 and DSPE-PEG-cRGD encapsulated IR-1048 nanoparticles (FINPs) exhibiting absorption peak up to 1,064 nm were utilized as contrast agents to enhance NIR-PAM for in vivo imaging of fundus tissues. The fundus structure and vessels are clearly visualized by the multimodal imaging, and their parameters were quantitatively analyzed. NIR-PAM and OCT imaging of fundus were time-serially monitored over 60 min following the intravenous injection of FINPs into rats. The results indicated a 134 % increase in image signals in PAM at 1 min, along with an 8.23 % intensity enhancement in OCT. Moreover, laser-induced choroidal neovascularization (CNV) was specifically detected and accurately quantified using VIS/NIR-PAM-OCT. Lastly, FINPs demonstrated excellent biocompatibility in hematology analysis and pathology testing.

譯文：

在這篇論文中，我們設計了一種多模式可見/近紅外光聲顯微鏡和光學相干斷層掃描（VIS/NIR-PAM-OCT）系統，用于對視網膜和視網膜色素上皮（RPE）/脈絡膜復合層進行成像。F127和DSPE-PEG-cRGD包封的IR-1048納米顆粒（FINP）具有高達1064nm的吸收峰，被用作造影劑，以增強眼底組織的NIR-PAM體內成像。多模態成像清晰地顯示了眼底結構和血管，并對其參數進行了定量分析。在大鼠靜脈注射FINP后60分鐘內，對眼底的NIR-PAM和OCT成像進行時間序列監測。結果表明，1分鐘后PAM的圖像信號增加了134%，OCT的強度增強了8.23%。此外，使用VIS/NIR-PAM-OCT專門檢測并準確定量了激光誘導的脈絡膜新生血管（CNV）。最后，FINP在血液學分析和病理學測試中表現出*的生物相容性。

DOI：10.1515/nanoph-2023-0872

西安齊岳生物提供相關產品：

DSPE-PEG-OH

DSPE-PEG-HZ

DSPE-PEG-Mal

DSPE-PEG-N3

DSPE-PEG-NH2 CAS No.: 474922-26-4

DSPE-PEG-NHS

DSPE-PEG-Alkyne

DSPE-PEG-Biotin

DSPE-PEG-CHO

DSPE-PEG-DSPE

DSPE-PEG-Dextran

DSPE-PEG-DBCO CAS No.: 2052955-83-4

DSPE-PEG-FA，DSPE-PEG-Folate，

DSPE-PEG-OPSS

DSPE-PEG-6-FAM

DSPE-PEG6-Mal

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