產品名稱：

Artesunate，88495-63-0，butanedioic acid

產地：西安

規格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

溫馨提示：僅用于科研，不能用于人體實驗！

Artesunate is a derivative of artemisinin (Item No. 11816) that is active against P. falciparum in vitro (IC50 = 1.28 nM).1 It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge.2 It inhibits the activity of the P. falciparum EXP1, a glutathione S-transferase (GST) that degrades hematin, with an IC50 value of 2.05 nM.3 Artesunate inhibits proliferation of germinal center B cells in vitro and prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis when administered at a dose of 100 mg/kg twice per day.4 It also inhibits alveolitis and pulmonary fibrosis induced by bleomycin (Item No. 13877) in rats.5 Artesunate increases the activity of GST in mice infected with P. berghei compared to uninfected and infected control animals.6

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編輯：XAQYBIO HAO，2023年3月15日。