產品名稱：

BGP-15，66611-37-8

產地：西安

規格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

溫馨提示：僅用于科研，不能用于人體實驗！

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis.1 BGP-15 is a PARP inhibitor and insulin sensitizer. In perfused heart, it blocks self-ADP-ribosylation of nuclear PARP (Ki = 57 μM) and mono-ADP-ribosylation of GRP78, resulting in decreased levels of reactive oxygen species, lipid peroxidation, and single-strand DNA breaks.2,3 BGP-15 acts as a co-inducer of heat shock protein 72, augmenting expression induced by heat shock factor 1 in adipocytes and skeletal muscles and improving insulin sensitivity.

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編輯：XAQYBIO HAO，2023年3月15日。