文獻：順鉑負載EGF修飾mPEG-PLGA-PLL納米粒子對小鼠SKOV3癌的毒性及*作用

鏈接：https://www.sciencedirect.com/science/article/abs/pii/S0142961212014135

作者：王云飛 a b 1，劉培峰 c 1，邱麗華 a b，孫英  ，朱明杰  ，顧麗英 a b，溫迪   ，段 友容c

節選：

構建具有低毒性和特異性*靶向性的納米粒子具有挑戰性，需要仔細設計納米粒子的組成、尺寸和物理化學性質。這里制備了表皮生長因子（EGF）修飾的甲氧基聚乙二醇-聚乳酸-乙醇酸-聚賴氨酸（mPEG-PLGA-PLL）包裹的順鉑（CDDP）納米粒子（CDDP-NPs-EGF）以解決 CDDP 的毒性并提高*效率。CDDP-NPs-EGF 的顯著特點是在體外增加細胞毒性，這歸因于有效的細胞周期停滯和高細胞凋亡。在體內，CDDP-NPs-EGF 改變了藥物分布，降低了CDDP 的腎毒性，顯著提高了*效率，而沒有引起明顯的系統毒性，驗證了其在降低藥物毒性和增強小鼠SKOV3 癌**效率方面的關鍵作用。

Construction on the nanoparticles with lower toxicity and specific tumor targeting properties is challenging and requires careful design of composition, size, physicochemical properties tailored for the nanoparticles. Here the epidermal growth factor (EGF) modified methoxy polyethylene glycol-polylactic-co-glycolic acid-polylysine (mPEG-PLGA-PLL) encapsulated cisplatin (CDDP) nanoparticles (CDDP-NPs-EGF) was prepared to for solving the toxicity of CDDP and improving therapeutic efficiency. The remarkable features of CDDP-NPs-EGF are increasing cytotoxicity that attribute to effective cell cycle arrest and high cell apoptosis in vitro. In vivo, the CDDP-NPs-EGF change drug distribution, decrease the nephrotoxicity of CDDP and improve significantly therapeutic efficiency without inducing obvious system toxicity, verifying its key role of the CDDP-NPs-EGF in lowering drug toxicity and enhancing the antitumor efficiency for SKOV3 cancer in mice.

西安齊岳生物提供相關產品：

PLL(20)-g[3.5]-PEG(2)，多聚賴氨酸支鏈共聚聚乙二醇，Poly-L-lysine2500-g[3.5]-PEG88

PLL(20)-g[5]-PEG(2)

PLL(30)-g[3.5]-PEG(2)

PLL(30)-g[5]-PEG(2)

PLL(20)-g[3.5]-PEG(4)

PLL(20)-g[5]-PEG(4)

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