文獻：Palladium cubes with Pt shell deposition for localized surface plasmon resonance enhanced photodynamic and photothermal therapy of hypoxic tumors?

作者：Wenxiang Gu ab, Zhiyuan Hua b, Zheng Li ab, Zhiheng Cai a, Wandong Wang a, Kaijin Guo b, Feng Yuan b, Fenglei Gao ORCID logo*a and Hongliang Chen

文獻鏈接：https://pubs.rsc.org/en/content/articlehtml/2022/bm/d1bm01406d

摘要：

Multifunctional phototherapy nanoagents for imaging-guided synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) are highly desirable in the field of solid tumor therapy. Nevertheless, the tumor microenvironment (TME) inherently associated with hypoxia significantly hampers the photodynamic effect of these multifunctional nanoagents. Herein, Pd nanocubes coated with an ultrathin Pt shell were prepared and further conjugated with fluorescein labeled and thiol functionalized polyethylene glycol (FITC-PEG-SH) (denoted as Pd@Pt-PEG). The deposition of a Pt shell on Pd nanocubes not only enhances the photothermal performance, exhibiting excellent hyperthermia outcomes and impressive photothermal (PT) imaging quality, but also leads to the formation of singlet oxygen (1O2) induced by plasmonic excitation. In the meantime, the catalytic activity of the Pt layer is enhanced by electronic coupling and the plasmonic effect, which induces the decomposition of endogenous overexpressed hydrogen peroxide (H2O2) in tumors to generate O2 for conquering TME and augmenting 1O2 generation for efficacious tumor cell apoptosis. The modification of FITC-PEG-SH improves the biocompatibility and provides outstanding fluorescence (FL) imaging properties. Upon NIR laser irradiation, Pd@Pt-PEG allows in situ O2 generation and dual-mode imaging-guided synergistic PTT/PDT that effectively kills hypoxic tumor cells, which makes it a promising nanotherapeutic agent for enhanced tumor therapy.

用于成像引導的協同光熱療法（PTT）和光動力療法（PDT）的多功能光療納米劑在實體瘤治療領域受歡迎。然而，與缺氧固有相關的腫瘤微環境（TME）顯著阻礙了這些多功能納米藥物的光動力效應。

在此，制備了涂有超薄Pt殼的Pd納米立方體，并進一步與熒光素標記和巰基官能化的聚乙二醇（FITC-PEG-SH）（表示為Pd@Pt-PEG).Pt殼在Pd納米立方體上的沉積不僅增強了光熱性能，表現出優異的熱療效果和令人印象深刻的光熱（Pt）成像質量，而且還導致等離子體激發誘導的單線態氧（1O2）的形成。

同時，Pt層的催化活性通過電子耦合和等離子體效應得到增強，這誘導了腫瘤中內源性過表達的過氧化氫（H2O2）的分解，產生O2以征服TME，并增加1O2的產生以實現有效的腫瘤細胞凋亡。FITC-PEG-SH的改性提高了生物相容性，并提供了出色的熒光（FL）成像性能。

在NIR激光照射下，Pd@Pt-PEG允許原位O2生成和雙模成像引導的協同PTT/PDT，有效殺死缺氧腫瘤細胞，這使其成為增強腫瘤治療的有前景的納米治療劑。

相關推薦：

FITC-PEG-DTPA

FITC-PEG-Estrogen

FITC-PEG-LA

FITC-PEG-MTX

FITC-PEG-Niacin

FITC-PEG-OPSS

FITC-PEG-PCL(2K)

FITC-PEG-PCL(5K)

FITC-PEG-Progestrone

FITC-PEG-SC

FITC-PEG-Silane

FITC-PEG-Tretinoin

ICG-PEG-Alkyne

ICG-PEG-Biotin

以上文章內容來源各類期刊或文獻，如有侵權請聯系我們刪除！