文獻：PLGA-卵磷脂-PEG核殼納米粒子用于癌癥靶向*

鏈接：https://www.worldscientific.com/doi/abs/10.1142/S1793984411000359

作者：鄭明斌， 乒乓球， 賈冬雪， 鄭翠芳， 馬一帆， 和 蔡林濤

節選：

我們報道了一種多功能聚乳酸-乙醇酸共聚物 (PLGA)-卵磷脂-聚乙二醇 (PEG) 核殼納米粒子 (NPs)，該納米粒子兼具脂質體和聚合物納米粒子的優點，可用于遞送化療藥物。該納米粒子的粒徑、表面電荷和表面官能團可通過各種配方參數輕松調節，且重復性高，例如脂質/聚合物、1,2-二硬脂酰-sn-甘油-3-磷酸乙醇胺 (DSPE)-PEG- COOH /卵磷脂、DSPE-PEG- COOH /DSPE-PEG- NH 2 的質量比以及 DSPE-PEG 端基的修飾。我們將模型化療藥物——親水性順鉑 (DDP) 或疏水性 DDP 前藥——封裝于納米顆粒 (NP) 中，結果顯示其包封率高、穩定性佳、對高 FA 受體表達的 MCF-7 細胞具有特異性靶向識別能力，且 FA 受體表達量高，且細胞毒性較小。此類 PLGA-卵磷脂-PEG 核殼納米顆粒 (NP) 已被證明是一種*具潛力的癌癥靶向*藥物遞送納米載體。

Abstract

We reported the development of multifunctional poly (lactic-co-glycolic acid) (PLGA)-lecithin-polyethylene glycol (PEG) core-shell nanoparticles (NPs) that combined the beneficial properties of liposome and polymeric NPs for chemotherapeutics delivery. The particle size, surface charge and surface functional groups were easily tunable in highly reproducible manner by various formulation parameters such as lipid/polymer, 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-PEG-COOH/lecithin, DSPE-PEG-COOH/DSPE-PEG-NH2 mass ratio and modification of terminal groups of DSPE-PEG. We encapsulated model chemotherapy drug, hydrophilic cisplatin (DDP) or hydrophobic DDP prodrug, in the NPs and showed high encapsulation efficiency, excellent stability, specific FA targeting recognition for MCF-7 cells with over FA receptors expression and pretty cytotoxicity. Such PLGA–lecithin–PEG core-shell nanoparticles (NPs) were proved to be a promising drug delivery nanocarrier for cancer-targeted therapy.

西安齊岳生物提供相關產品：

C18-PEGn-NH2 (NH2: Amine)

DSPE-PEG-GRGDS

DSPE-PEG-Insulin

DSPE-PEG-Chitosan

DSPE-PEG-Alginate

DSPE-PEG-KAA(CKAAKNK)（二硬脂酰基磷脂酰乙醇胺-聚乙二醇-*靶向蛋白)

DPPE-mPEG

DSPE-PEG-TRITC

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