DSPE-PEG-MTX修飾納米膠束在頭頸部鱗狀細胞癌中的靶向應用研究

鏈接：https://www.tandfonline.com/doi/abs/10.2217/nnm-2016-0382

作者：朱敏慧，陳世才，華立波，張彩云，陳夢潔，陳東輝，董銀梅，張瑩瑩，李萌，宋憲民，陳懷文  ，鄭洪亮

摘要：

目的：利用載鹽霉素的DSPE-PEG-MTX（由DSPE-PEG2000-NH2和甲氨蝶呤合成）納米膠束（M-SAL-MTX）同時靶向作用于頭頸部鱗狀細胞癌（HNSCC）細胞和*干細胞（CSC）。

材料與方法：評估M-SAL-MTX的表征、**活性和作用機制。

結果與結論：與單一甲氨蝶呤和鹽霉素*相比，M-SAL-MTX對HNSCC CSC和非CSC均顯示出增強的抑制作用。在攜帶HNSCC異種移植瘤的裸鼠中，M-SAL-MTX抑制*生長的效果優于其他對照組（包括甲氨蝶呤和鹽霉素聯合用藥）。因此，M-SAL-MTX可能提供一種同時靶向HNSCC CSC和HNSCC細胞的*HNSCC的策略。

Abstract

Aim: To target both head and neck squamous cell carcinoma (HNSCC) cells and cancer stem cells (CSCs) by salinomycin-loaded DSPE-PEG-MTX (synthesized using DSPE-PEG2000-NH2 and methotrexate) nanomicelles (M-SAL-MTX). Materials & methods: The characterization, antitumor activity and mechanism of M-SAL-MTX were evaluated. Results & conclusion: M-SAL-MTX showed enhanced inhibitory effect toward both HNSCC CSCs and non-CSCs compared with a single treatment of methotrexate and salinomycin. In nude mice-bearing HNSCC xenografts, M-SAL-MTX suppressed tumor growth more effectively than other controls including combination of methotrexate and salinomycin. Therefore, M-SAL-MTX may provide a strategy for treating HNSCC by targeting both HNSCC CSCs and HNSCC cells.

西安齊岳生物提供相關產品：

DSPE-PEG-NB

DSPE-PEG-NBD

DSPE-PEG-NPC

DSPE-PEG-NTA-NI

DSPE-PEG-PCL

DSPE-PEG-PDP

DSPE-PEG-PEI

DSPE-PEG-PLA

DSPE-PEG-PLGA

DSPE-PEG-Progestrone

DSPE-PEG-RGD

DSPE-PEG-SC

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