文獻：Research on paclitaxel microemulsion

文獻鏈接：https://xueshu.baidu.com/usercenter/paper/show?paperid=711ecf9ab37cd13cc80ce6b099adfed6&site=xueshu_se

作者：閻家麒，王惠杰，童巖，臧瑩安，王九一

摘要：

OBJECTIVE:To study the preparation of microemulsion containing paclitaxel for both intravenous and oral administration,its stability and bioavailability. METHODS:Corn oil was hydrated and sonicated.EPC,paclitaxel and PEG-DSPE were combined in CHCl-3.A thick lipid film was obtained after drying under a stream of N-2 and vacuum evacuation.The hydrated oil was added directly to the thin phospholipid film,vortexed and then sonicated.The mixture was passed through the Microfluidizer for microemulsified. RESULTS:The particle size was 50～100 nm,the encapsulation efficiency was ≥99.2% and the absolute bioavailability of intravenous and oral adminstration was 107.7% and 22.4%,respectively. CONCLUSION:This study developed a new formulation for paclitaxel.

目的：研究紫杉醇靜脈和口服微乳的制備、穩定性和生物利用度。

方法：將玉米油水合并超聲處理。EPC、紫杉醇和PEG-DSPE在CHCl-3中混合。在N-2流和真空抽空下干燥后獲得厚脂質膜。將水合油直接加入薄磷脂膜中，渦旋，然后超聲處理。將混合物通過微流化器進行微乳化。

結果：粒徑為50～100nm，包封率≥99.2%，靜脈和口服給藥的絕對生物利用度分別為107.7%和22.4%。

結論：本研究開發了一種新的紫杉醇制劑。

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