文獻：mPEG接枝α-玉米醇溶蛋白聚合物及其制備方法

作者：宋镕光，石彤非，李帆

文獻鏈接：https://xueshu.baidu.com/usercenter/paper/show?paperid=17360jn0wx0t0xd0c11e0v003n660515&site=xueshu_se

摘要：

The present invention relates to an mPEG grafted alpha zein polymer and its preparation method, which solves the technical problem of using zein as a coating material for drugs and nutrients, which is not conducive to controlling drug release and uniform particle size distribution The polymer was first prepared by reacting mPEG with succinic anhydride to obtain mPEG COOH; Then, mPEG COOH was reacted with α - zein to prepare mPEG grafted α - zein polymer The mPEG grafted alpha zein polymer prepared by the method of the present invention can form stable and uniformly sized microspheres (particle size between 80-100nm) after dissolving in water, which are smaller than the particle size of mixed zein and can improve the controlled release and bioavailability of hydrophobic drugs and nutrients

本發明涉及一種mPEG接枝α-玉米醇溶蛋白聚合物及其制備方法,解決現有玉米醇溶蛋白作為藥物和營養素的包裹材料,不利于控制藥物的釋放與粒徑分布均一的技術問題.該聚合物首先由mPEG與丁二酸酐反應制備得到mPEG-COOH;再由mPEG-COOH與α-玉米醇溶蛋白反應制備得到mPEG接枝α-玉米醇溶蛋白聚合物.本發明方法制備得到的mPEG接枝α-玉米醇溶蛋白聚合物溶于水后,能夠形成穩定存在且尺寸均一的微球(粒徑在80-100nm),比混合的玉米醇溶蛋白的粒徑小,可提高疏水類藥物,營養素的可控釋放和生物利用率.

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